Isolation, identification, and pathogenicity of a NADC30-like porcine reproductive and respiratory disorder syndrome virus strain affecting sow production

Since it was first reported in 1987, porcine reproductive and respiratory syndrome virus (PRRSV) has caused several economic crises worldwide. The current prevalence of PRRSV NADC30-like stains causing clinical disease outbreaks Chain is highly concerning. Immunization against the prevention this infection are burdensome for farming organizations as pathogen frequently mutates undergoes recombination. Herein, genetic characterization a strain (termed BL2019) isolated from farm Guangdong Province, China, analyzed its pathogenicity piglets sows assessed. Results revealed that BL2019 exhibits nucleotide homology 93.7% with NADC30 NSP2 coding region demonstrates same 131aa deletion pattern NADC30-like. Furthermore, we identified two recombination breakpoints located nt5804 NSP5-coding nt6478 NSP2-coding region, gene fragment between showed higher to TJ strain(a representative pathogenic PRRSV) compared strain. In addition, fever lasting 1 week, moderate signs obvious visual microscopic lung lesions; gestating affected their feed intake increased body temperature, abortion rates, number weak fetuses, other undesirable phenomena. Therefore, report partial HP-PRRSV, TJ, can provide early warning support PRRS immune control.